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The move by Eli Lilly came less than 24 hours after Johnson & Johnson paused further dosing in all of its COVID-19 vaccine candidate clinical trials while it investigated a volunteer's illness.
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The pledge comes one month after a survey found that only 2 in 5 Americans said they planned to get vaccinated against COVID-19.
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This is the sixth vaccine candidate to join Operation Warp Speed's portfolio, and the largest vaccine deal to date.
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If the company's vaccine candidate pans out, Americans can receive it for free under the deal. The arrangement is part of the U.S. government's push to have a vaccine widely available by January.