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The legislation removes cannabis from the list of federally controlled substances and expunges low-level convictions and arrests. But the GOP Senate is not expected to take up the bill.
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House Speaker Nancy Pelosi and Senate Minority Leader Chuck Schumer are breaking from their demand for more than $2 trillion in coronavirus relief spending to move toward a compromise.
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The vice president made his first campaign appearance since he and President Trump lost their bid for reelection. He boosted Senate Republicans, while sidestepping the president's fraud claims.
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The House has a critical to-do list for a new Congress, which includes leadership and legislative battles. Lawmakers still have business for the lame duck session, but now will have testing protocols.
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The latest cases highlight the absence of a widespread testing program for Congress more than seven months after the World Health Organization declared a pandemic.
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With tens of thousands already out of work, travel industry groups warn another 1.3 million jobs could be lost if Congress and the White House fail to reach agreement on coronavirus relief soon.
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But a top aide to Speaker Nancy Pelosi tweeted that she spoke to the treasury secretary Wednesday about a standalone measure to help airlines. A previous attempt to do this failed amid GOP opposition.
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Earlier Tuesday, Federal Reserve Chairman Jerome Powell urged more congressional action to help the economy recover from the recession caused by the pandemic.
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Democrats and Republicans were split in their public reaction to President Trump's recent remarks.
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The legislation addresses many of Democrats' top priorities that were included in the $3.4 trillion bill that passed the House in May. The latest bill lessens the duration of benefits.