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Democratic Rep. Bruce Braley was considered the favorite to capture the state's open U.S. Senate seat. But an injudicious remark he made about veteran GOP Sen. Charles Grassley has unsettled the race.

Congressional Republicans say they want to repeal and replace Obamacare, but they've been light on details of what the alternative might look like.

Strained relations between Afghanistan and the U.S. and NATO may only get worse this week. The Afghan government is releasing 65 prisoners, many of whom have been accused by the West of plotting and participating in terrorist activities. Robert Siegel speaks with Nathan Hodge of The Wall Street Journal to learn more about the rationale behind this release and what it might mean for Afghan security and diplomacy.

New York Gov. Andrew Cuomo was expected to cruise to victory in next Tuesday's Democratic primary. But he faces a surprisingly vigorous challenge from the left.

Where did Lear get the confidence to spend three years fighting to get All In The Family on air? His answer: "Can you say 'beats the **** out of me' on NPR?"

Infectious disease specialists say Ebola can't spread through the air, but many Americans remain deeply skeptical. The history of past outbreaks suggests airborne transmission isn't a threat.

The White House abruptly cancelled President Obama's campaign trip on Wednesday so he could hold a meeting on the federal response to Ebola.

Calling the looming government shutdown a reckless Republican strategy, Democrat Alison Lundergan Grimes is accusing incumbent U.S. Sen. Mitch McConnell, R

Federal Reserve chairmen used to be named without much fanfare. Not this time. A very public competition between former Treasury Secretary Larry Summers and the current vice chairman of the Fed Janet Yellen has made headlines and pitted the White House against liberal Democrats in Congress. It raises the question of whether the Fed succession has become too politicized — and whether it could ultimately hurt the economy.

Iran's new president has made his first appearance at the United Nations General Assembly. Hassan Rouhani has been signaling that his government wants a thaw in relations with the West, and may be ready to strike a deal on Iran's suspect nuclear program. There are, however, deep suspicions on both sides.